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Current Issues on GEJ Adenocarcinoma

Surgery is no longer the only way to treat this aggressive disease. A multimodal approach with preoperative chemo and chemo-radiotherapy is the standard care in most cases and the evaluation of the response to these treatments with new techniques such as MRI, represent a new field of investigation and development. Identification and prediction of response to various treatment modalities is a very promising field of research for proper patient selection. An important step forward has also been made with the development of endoscopic resection for early stage disease, avoiding “overtreatment”, leaving intact the esophageal function with a better long term quality of life.

Epidemiology, Biomarkers and Modelling of Gastroesophageal Reflux Disease

This special series on Epidemiology, Biomarkers and Modelling of Gastroesophageal Reflux Disease was co-edited by Dr. Peter W. Dettmar from Technostics Ltd & RD Biomed Ltd, Castle Hill Hospital, East Yorkshire, UK; and Dr. Jeffrey P. Pearson from Newcastle University Biosciences institute, The Medical School, Framlington Place, Newcastle upon Tyne, UK.

AOE Annual Report (2020)

Greetings from the Editorial Office of Annals of Esophagus (AOE).

Till Dec. 31, 2020, AOE has a total of 66 members on board, from 18 countries. With joint effort and support from editorial board members, authors, guest editors and reviewers, AOE published 40 articles with about 63% are Review Articles and 12% Original Articles. Corresponding Authors were from various countries with Australia and USA among the most. According to the Google Analytics, AOE had an increasing number of pageviews and visitors (all together 16,969 visitors worldwide and 53,254 pageviews). For more details, please see the following report.

New Technologies in Esophageal Surgery and Endoscopy (Ongoing)

This special series on New Technologies in Esophageal Surgery and Endoscopy is co-edited by Dr. Abbas E. Abbas and Dr. Roman V. Petrov, from Temple University and Fox Chase Cancer Center, Philadelphia, PA, USA.

Minimally Invasive Procedures for Gastroesophageal Reflux Disease (Ongoing)

This special series on Minimally Invasive Procedures for Gastroesophageal Reflux Disease are co-edited by Dr. Timothy M. Farrell, from University of North Carolina School of Medicine, Chapel Hill, NC, USA; and Dr. Geoffrey Kohn, from Monash University, Melbourne, Australia.

Anastomotic Techniques for Minimally Invasive Esophagectomy and Endoscopic Handling of Its Complications (Ongoing)

This special series on Anastomotic Techniques for Minimally Invasive Esophagectomy and Endoscopic Handling of Its Complications is edited by Dr. Alejandro Nieponice, from Hospital Universitario Fundacion Favaloro, Buenos Aires, Argentina.

Endoscopic Eradication Therapy in Barrett’s Esophagus (Ongoing)

This special series guest edited by Dr. Madhav Desai aims to review existing standards, technologies and tools for endoscopic therapy of Barrett’s Esophagus with special focus on dysplasia and early neoplasia. This field is constantly evolving with great strides in recent years. Our goal is also to learn from those excellent international experts who have contributed in this field significantly and have years of experience in the management of Barrett’s esophagus related neoplasia. Hopefully. this endeavor will help practicing gastroenterologists and trainees that will ultimately benefit our patients.

Novel Developments in the Multimodality Treatment of Esophageal Cancer (Ongoing)

This special series on “Novel Developments in the Multimodality Treatment of Esophageal Cancer” is edited by Drs. Sjoerd Lagarde and Bas Wijnhoven, from Erasmus Medical Center, Rotterdam, The Netherlands; and Dr. Florian Lordick, from Universitätsklinik Leipzig, Leipzig, Germany.

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Letter to the Editor

Bile acids are risk factors for esophageal carcinogenesis

Naoki Hashimoto

Annals of Esophagus

2021;

(25 June 2021)

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Case Report

Unusual approach for treatment of esophageal cancer in a patient with right-sided aortic arch: a case report

Yala Kirthi Reddy, Asra K. Butt, Claudio R. Tombazzi, Qasim M. Mirza

Annals of Esophagus

2021;

(25 June 2021)

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Review Article

Neoadjuvant treatment in esophageal cancer—established treatments and new developments reviewed

Bianca Mostert, Ate van der Gaast

Annals of Esophagus

2021;

(25 June 2021)

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Review Article

Minimally invasive esophagectomy: anastomotic techniques

Rebecca A. Carr, Daniela Molena

Annals of Esophagus

2021;

(25 June 2021)

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Review Article

Ivor Lewis minimally invasive esophagectomy

Gail E. Darling

Annals of Esophagus

2021;

(25 June 2021)

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Review Article

Surgery and adjuvant therapy after esophagectomy

Satoru Matsuda, Hirofumi Kawakubo, Shuhei Mayanagi, Tomoyuki Irino, Yuko Kitagawa

Annals of Esophagus

2021;

(25 June 2021)

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Review Article

Minimally invasive McKeown esophagectomy: a narrative review of current operative and oncologic outcomes

James J. Choi, Smita Sihag

Annals of Esophagus

2021;

(25 June 2021)

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Original Article

Total gastrectomy versus upper pole gastrectomy for the surgical therapy of Siewert type II adenocarcinoma of the esophagus: pathology may drive the choice

Marialuisa Lugaresi, Benedetta Mattioli, Niccolò Daddi, Vladimiro Pilotti, Luca Ferruzzi, GianDomenico Raulli, Deborah Malvi, Antonietta D’Errico, Roberto Fiocca, Sandro Mattioli

Annals of Esophagus

2021;

(25 June 2021)

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Original Article

Pepsin as a biomarker of reflux in patients presenting at a UK ENT voice clinic

Peter W. Dettmar, Katie H. A. Boulton, Andrew D. Woodcock, Rhianna K. Lenham, Mark Watson

Annals of Esophagus

2021;

(25 June 2021)

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Review Article

Medical management of acid/bile reflux before, during and after endoscopic therapy for Barrett’s esophagus: a narrative review

Tamika Jaswani, Ashton C. Ellison, Vani J. A. Konda

Annals of Esophagus

2021;

(25 June 2021)

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Editorial

The cutting edges of esophageal cancer management

Riccardo Rosati

Annals of Esophagus

2021;

(25 June 2021)

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Case Report

Recurrent esophageal candidiasis: a case report of different complications

Siok Siong Ching, Teik Wen Lim, Ya-Lyn Annalisa Ng

Annals of Esophagus

2021;

(25 March 2021)

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Review Article

The impact of prehabilitation on surgical outcomes

Enrico Maria Minnella, Kenneth Drummond, Francesco Carli

Annals of Esophagus

2021;

(25 March 2021)

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Review Article

Open, hybrid or total minimally invasive esophagectomy; a comprehensive review based on a systematic literature search

William Jebril, Fredrik Klevebro, Ioannis Rouvelas, Magnus Nilsson

Annals of Esophagus

2021;

(25 March 2021)

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Review Article

Anastomotic leakage after esophagectomy for esophageal cancer: risk factors and operative treatment

Sander Ubels, Moniek H. P. Verstegen, Camiel Rosman, John V. Reynolds

Annals of Esophagus

2021;

(25 March 2021)

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Review Article

Robotic-assisted minimally invasive esophagectomy

Chigozirim N. Ekeke, James D. Luketich, Inderpal S. Sarkaria

Annals of Esophagus

2021;

(25 March 2021)

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Review Article

Optimization of detection of residual disease after neoadjuvant therapy in patients with esophageal cancer

Maria J. Valkema, Michail Doukas, Manon C. W. Spaander, Roelf Valkema, Henry C. Woodruff, J. Jan B. van Lanschot

Annals of Esophagus

2021;

(25 March 2021)

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Original Article

Neoadjuvant versus adjuvant chemoradiotherapy for esophageal carcinoma: a systematic review and meta-analysis

Li Zhang, Yichun Wang, Wanli Xia, Ningning Kang, Mei Kang, Liyang Zhu, Dongbo Chen, Li Niu, Yu Gao, Mingwei Yang, Liming Wu

Annals of Esophagus

2021;

(25 March 2021)

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Original Article

Development of an infant stomach model: validation of products targeting reflux in neonates and infants

Jeanine Fisher, Katie H. A. Boulton, Peter W. Dettmar

Annals of Esophagus

2021;

(25 March 2021)

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Original Article

Airway resection for cT4b esophageal cancer: a single institution experience

Aroub Alkaaki, Stephane Renaud, Maude Trépanier, Jonathan Cools-Lartigue, Jonathan Spicer, Carmen Mueller, Lorenzo Ferri

Annals of Esophagus

2021;

(25 March 2021)

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Original Article

Pepsin as a biomarker for self-diagnosing reflux associated symptoms in UK and USA individuals

Katie H. A. Boulton, Jeanine Fisher, Andrew D. Woodcock, Peter W. Dettmar

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Changes in gastric perfusion during oesophagectomy using real time laser doppler imaging may predict patients at risk of anastomotic complications

Mark Kelly, James Gossage

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Original observational study on disparate treatments for achalasia experienced by patients of white British and South Asian ethnicity

Affifa Farrukh, John F. Mayberry

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Personalized surgical management of esophagogastric junction cancers: retrospective cohort study at a Canadian institution

Anitha Kammili, Jose L. Ramirez-GarciaLuna, Carmen L. Mueller, Jonathan Spicer, Lorenzo E. Ferri, Jonathan Cools-Lartigue

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Esophageal cancer in young patients: does age affect treatment course and outcomes?

Ethan Y. Song, Samer A. Naffouje, Sabrina Saeed, Alexander Glaser, Miles Cameron, Jacques Fontaine, Luis Pena, Mark Friedman, Rutika Mehta, Sarah E. Hoffe, Jessica M. Frakes, Jose M. Pimiento

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The rheological properties of an alginate satiety formulation in a physiologically relevant human model gut system

Matthew D. Wilcox, Peter I. Chater, Kyle J. Stanforth, Andrew D. Woodcock, Peter W. Dettmar, Jeffrey P. Pearson

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Linear stapled technique for robotic assisted minimally invasive esophagectomy

Gijsbert I. van Boxel, Nicholas C. Carter, Benjamin C. Knight, Veronika Fajksova, Nicholas Jenkins, Khalid Akbari, Stuart J. Mercer

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Results of comprehensive dysphagia evaluation and delayed oral intake following esophagectomy

Andrew M. Blakely, Oliver S. Eng, Rebecca A. Nelson, Loretta Erhunmwunsee, Dan J. Raz, I. Benjamin Paz, Jae Y. Kim

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The prognostic role of positive circumferential resection margins after curative intent surgery for locally advanced esophageal adenocarcinoma

Élise Di Lena, Juan Carlos Molina, Aya Siblini, Caroline Huynh, Carmen Mueller, Jonathan Spicer, David Mulder, Lawrence Lee, Lorenzo Ferri, Jonathan Cools-Lartigue

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Minimally invasive Ivor-Lewis esophagectomy with linear stapled side-to-side anastomosis

Henricus J. B. Janssen, Grard A. P. Nieuwenhuijzen, Misha D. P. Luyer

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Robot-assisted hand-sewn intrathoracic anastomosis after esophagectomy

Eline M. de Groot, Feike B. Kingma, Lucas Goense, Sylvia van der Horst, Jan Willem van den Berg, Richard van Hillegersberg, Jelle P. Ruurda

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Technical notes and outcomes of robot-assisted and laparoscopic jejunostomy placement for tube feeding after esophagectomy

B. Feike Kingma, Matias M. Turchi, Romina Lovera, Mauricio Ramirez, Adolfo Badaloni, Richard van Hillegersberg, Jelle P. Ruurda, Alejandro Nieponice

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Review Article

Learning curves and safe implementation of minimally invasive esophagectomy

Frans van Workum, Frits J. H. van den Wildenberg, Fatih Polat, Maroeska M. Rovers, Camiel Rosman

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A narrative review of endoscopic therapies in Barrett’s esophagus

Nour Hamade, Prateek Sharma

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Future directions—minimally invasive approaches to esophageal resection: a narrative review

Sarah Yousef, James D. Luketich, Inderpal S. Sarkaria

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Endoscopic treatments for early gastroesophageal lesions

Sachin Srinivasan, Nour Hamade, Fabian Emura, Prateek Sharma

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Indication for the endoscopic treatment of Zenker’s diverticula

María Rita Rodríguez-Luna, Margherita Pizzicannella, Silvana Perretta

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Novel endoscopic therapies in Barrett’s esophagus: narrative review

Gaia Pellegatta, Arianna Dal Buono, Alessandro Repici

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Indications for definitive chemoradiotherapy for oesophageal cancer

Sweet Ping Ng, Trevor Leong

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Palliation of malignant dysphagia: stent or radiotherapy?

Lieke M. Koggel, Marten A. Lantinga, Peter D. Siersema

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Role of surgery in the management of synchronous metastatic esophageal cancer

Mickael Chevallay, Minoa Jung, Charles-Henri Wassmer, Stefan Mönig

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Surgery for metachronic metastasized esophageal cancer

Dimitrios Schizas, Michail Vailas, Maria Sotiropoulou, Alkistis Kapelouzou, Theodore Liakakos

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In vitro modelling of the mucosa of the oesophagus and upper digestive tract

Kyle Stanforth, Peter Chater, Iain Brownlee, Matthew Wilcox, Chris Ward, Jeffrey Pearson

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Goals of endoscopic eradication therapy in Barrett’s esophagus: a narrative review

Charlotte N. Frederiks, Sanne N. van Munster, Bas L. A. M. Weusten

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Pharmacologic gut hormone modulation and eating behavior after esophagogastric cancer surgery: a narrative review

Nicholas RS Stratford, Conor F. Murphy, Jessie A. Elliott, John V. Reynolds, Carel W. le Roux

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“Functional approach” to esophageal body diverticula

Michele Marchese, Annalisa Capannolo, Antonio Giuliani, Sayali Valiyeva, Francesco Carlei, Loreto Lombardi

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A narrative review of the potential role of microaspiration and a dysregulated aerodigestive microbiome in lung disease

Abdullah Althuwaybi, Amal Alamer, Melissa J. McDonnell, Michelle Brennan, Robert M. Rutherford, Matthew Wilcox, Peter Chater, Jeffrey Pearson, Chris Ward

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Endoscopic management of patients with esophageal stricture in the oncology practice: a narrative review

Tomonori Yano, Hironori Sunakawa, Keiichiro Nakajo, Tomohiro Kadota, Yusuke Yoda

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Long term care after successful endoscopic therapy in Barrett’s esophagus patients: a review of literature

Sachin Srinivasan, Madhav Desai

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The future of therapy of Barrett’s esophagus and related cancer: a narrative review

Nastazja Dagny Pilonis, Massimiliano di Pietro

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A narrative review of the prevalence of gastroesophageal reflux disease (GERD)

Katie H. A. Boulton, Peter W. Dettmar

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Endoscopic therapy for Barrett’s esophagus: a narrative review of potential complications and their management

Sarah Enslin, Raseen Tariq, Vivek Kaul

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Minimally invasive surgery: hiatal hernia repair—a narrative review

Lina Hua, Geoffrey P. Kohn

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The upper esophageal sphincter in gastroesophageal reflux disease

Michelle Lippincott, Vic Velanovich

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Minimally invasive fundoplication for gastroesophageal reflux disease

Jeffrey N. Lipman, Timothy M. Farrell

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Colon interposition in the management of post-corrosive strictures

Venanzio Porziella, Diomira Tabacco, Edoardo Zanfrini, Jessica Evangelista, Maria Letizia Vita, Leonardo Petracca-Ciavarella, Luca Pogliani, Elisa Meacci, Maria Teresa Congedo, Marco Chiappetta, Stefano Margaritora, Dania Nachira

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A narrative review of minimally invasive fundoplication for gastroesophageal reflux disease and interstitial lung disease

Nicola Tamburini, Ciro Andolfi, P. Marco Fisichella

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A narrative review of current functional assessment of the upper esophageal sphincter

Rafael Melillo Laurino Neto, Fernando A. M. Herbella

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Endoscopic management of esophageal perforations and tears

Tommaso Schepis, Ivo Boškoski, Vincenzo Bove, Rosario Landi, Valerio Pontecorvi, Maria Valeria Matteo, Francesca Mangiola, Luca Sessa, Guido Costamagna

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A narrative review of the function of upper esophageal sphincter in the achalasia

Mariano de Almeida Menezes, Antônio Carlos Valezi, Fernando Augusto Mardiros Herbella

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Enhanced recovery after surgery pathway in esophagectomy in a high volume center: clinical keys to early leak diagnosis after esophagectomy

Jan Willem van den Berg, Sylvia van der Horst, Richard van Hillegersberg, Jelle P. Ruurda

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Pepsin properties, structure, and its accurate measurement: a narrative review

Kyle J. Stanforth, Matthew D. Wilcox, Peter I. Chater, Iain A. Brownlee, Maria I. Zakhour, Katherine M. R. M. Banecki, Jeffery P. Pearson

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Management of esophageal perforations and postoperative leaks

Dania Nachira, Carolina Sassorossi, Leonardo Petracca-Ciavarella, Edoardo Zanfrini, Diomira Tabacco, Luca Pogliani, Elisa Meacci, Maria Teresa Congedo, Maria Letizia Vita, Marco Chiappetta, Stefano Margaritora, Venanzio Porziella

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Choosing the right patient for laparoscopic fundoplication: a narrative review of preoperative predictors

Rippan N. Shukla, Jennifer C. Myers, Sarah K. Thompson

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Surgery versus active surveillance in clinical complete response

Giye Choe, Daniela Molena

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The Orvil end-to-side anastomosis for Ivor-Lewis minimally invasive esophagectomy: technique, considerations, and challenges

Andrew D. Grubic, Blair A. Jobe

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Surgical treatment of Zenker diverticula

Venanzio Porziella, Edoardo Zanfrini, Diomira Tabacco, Luca Pogliani, Maria Letizia Vita, Leonardo Petracca-Ciavarella, Elisa Meacci, Maria Teresa Congedo, Marco Chiappetta, Stefano Margaritora, Dania Nachira

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Endoscopic management of complications—endovacuum for management of anastomotic leakages: a narrative review

Carolina Mann, Felix Berlth, Evangelos Tagkalos, Edin Hadzijusufovic, Hauke Lang, Peter Grimminger

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Pre-operative evaluation of gastro-esophageal reflux disease

Sabine Roman

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Cricopharyngeal myotomy and toxin botulinum injection for the treatment of upper esophageal sphincter disorders: a narrative review

Francisco Laxague, Fernando A. M. Herbella, Francisco Schlottmann

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MIS revisional surgery for gastro-esophageal reflux disease: how I do it

Sarah K. Thompson, Rippan N. Shukla

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Prevention of stricture after semi-circumferential and whole circumferential esophageal endoscopic resection

Kotaro Waki, Ryu Ishihara

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Case Report

Laparoscopic Nissen fundoplication for gastroesophageal reflux disease in situs inversus totalis: a “self-solving puzzle”—a case report

Luciano Antozzi, Pedro Renda

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Editorial

Management of esophageal perforations and benign diseases

Dania Nachira, Venanzio Porziella

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Epidemiology, biomarkers and modelling of gastroesophageal reflux disease

Peter W. Dettmar, Jeffrey P. Pearson

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Study Protocol

McKeown—cervical anastomosis in minimally invasive esophagectomy

Flavio Roberto Takeda, Rubens Antonio Aissar Sallum, Felipe Alexandre Fernandes, Ivan Cecconello

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Journal Highlight more

Annals of Esophagus is an international, peer-reviewed, open-access journal focusing on basic and clinical research in all fields pertaining to the esophagus, including but no limited to esophageal cancer, Barrett's esophagus, gastroesophageal reflux disease, achalasia, hiatal hernias, esophagitis, congenital esophageal disease, esophageal diverticulum, esophageal perforation, benign esophageal neoplasms, and other rare esophageal malignancies.

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