Ivor Lewis minimally invasive esophagectomy
Overall, the minimally invasive approach to an Ivor Lewis esophagectomy is the same as the open operation. The goal of the operation is a complete (R0) resection of the cancer, with appropriate proximal, distal and radial margins and a complete lymph node dissection. The esophagus is reconstructed with stomach and the anastomosis is placed in the right chest. Laparoscopic/thoracoscopic cameras, instruments and techniques have been applied to the Ivor Lewis esophagectomy with excellent results, comparable to the open operation in terms of oncologic outcomes, and improved in terms of reduced pulmonary complications (1).
Minimally invasive Ivor Lewis esophagectomy is a technically challenging operation with a significant learning curve with some authors suggesting that more than 100 cases are required to be proficient whereas others report only 30–40 cases are needed (2-4). Robotic approaches may facilitate many parts of the operation however this is not the topic for this chapter.
In 1946 Ivor Lewis reported in the British Journal of Surgery his approach to carcinoma of the esophagus using a separate laparotomy and right thoracotomy (5). This approach became popular and was added to the armamentarium of esophageal surgeons (6). In 1992, Cuschieri reported on a totally minimally invasive approach to the Ivor Lewis esophagectomy (7). With the growth of minimally invasive surgery, esophagectomy was added to the list of procedures that could be approached in this manner (8). However it was James Luketich who really brought this operation into the mainstream, first reporting on his initial cases (9,10) and more recently on over 1,000 cases (11).
The technique for minimally invasive Ivor Lewis esophagectomy
There are multiple components of the operation which can be conducted in different sequence depending on the patient’s body habitus, the size and location of the tumour and the difficulty of the dissection.
The components are: the laparoscopic resection of the proximal stomach and preparation of the gastric conduit; the laparoscopic upper abdominal lymphadenectomy (D1 minimum), right thoracoscopic resection of the thoracic esophagus, mediastinal lymphadenectomy, delivery of the gastric conduit and esophagogastric anastomosis. Additional procedures including gastric emptying procedures and feeding jejunostomy may also be included although are less frequently used in the current era. See Table 1.
My approach follows, variations are noted
With the patient awake in the operating room, we review our first surgical checklist. The patient is then anaesthetized and intubated. A double lumen endotracheal tube is used from the start of the procedure rather than reintubating for the thoracic component. An arterial line, foley catheter and sequential compression devices are standard. Often a triple lumen central venous catheter is inserted in the right internal jugular vein which is used for postoperative TPN. Subcutaneous fractionated heparin is given and intravenous antibiotics are administered. A bronchoscopy and bronchoscopic washing for culture is performed. We have identified colonization of gram negative bacteria in some patients, and have been able to minimize the severity of postoperative pneumonia using this practice.
I prefer not to perform an endoscopy at the time of the planned resection. This introduces air into the stomach and bowel which can make the subsequent laparoscopic portion of the operation more challenging. In my practice, I will have usually performed endoscopy at the time of diagnosis or staging with EUS or prior to the start of neoadjuvant therapy. At the time of my initial endoscopy I note the upper extent of Barrett’s esophagus if present, the upper and distal extent of the tumor and the degree of involvement of the gastric cardia, or fundus. If I have not done an initial endoscopy, I will perform this prior to surgery but not on the day of surgery.
The patient is positioned supine on the operating table with all pressure points well padded. I prefer to keep both arms tucked at the side if possible. This prevents postoperative shoulder pain. The abdomen is prepped with chlorhexidine from above the nipple line to the symphysis pubis and from table side on the right to the left.
The second surgical checklist is reviewed and then the laparoscopic ports are placed. We infiltrate all port sites with 0.5% Marcaine with epinephrine prior to making the skin incisions. I use an open Hassan technique for the camera port which is generally placed several centimetres above the umbilicus. In patients with larger BMI, the port may be placed even higher. For very small patients, particularly if they have a narrow costal arch, the camera port is placed in the umbilicus. The abdomen is insufflated with CO2 to a sustained pressure of 15 mmHg. The camera is then inserted and the abdomen is inspected looking for evidence of carcinomatosis. Biopsy and quick section of any suspicious lesions is performed after placing an additional 5 mm port. If there is no evidence of metastatic disease, 4 more ports are inserted. Typically we use two 5 mm ports in the right and left subcostal positions laterally and two 12 mm ports in the epigastrium to the right and left of the midline with sufficient distance between these and the camera port. I choose to use two 12 mm ports so that I have flexibility when operating with a resident and can move the camera laterally to allow a more ergonomic approach when operating from either the right or left side of the patient. I use the 5 mm right subcostal port for the liver retractor. Alternatively, this could be placed in the subxiphoid position.
Dissection of the stomach
The gastrocolic, gastrosplenic and gastrohepatic ligaments are divided in this portion of the procedure. I use the ultrasonic shears energy device (Harmonic ACE with advanced hemostasis Ethicon/J&J US) for all dissection. I previously began by dividing the gastrocolic ligament, however, more recently, I have started by dividing the gastrohepatic ligament beginning at the pars flaccida and proceeding in a cephalad direction exposing the right crus (Figure 1A,B). I then divide the phrenoesophageal ligament beginning at the right crus and extending over to the left crus, exposing the left crus anteriorly (Figure 2).
The division of the gastrohepatic ligament is completed, and then the lesser curvature tissues are divided to the gastric wall. Previously these tissues were divided at the level of the incisura, I now divide these tissues to the gastric wall just below the crow’s foot. This will be the site for initiation of the gastric staple line. This completes this portion of the operation.
The gastrocolic ligament is then divided. This is facilitated by the operating surgeon gently grasping the anterior wall of the stomach with the left hand and elevating the stomach toward the hiatus while the assistant applies downward traction on the gastrocolic ligament near the edge of the transverse colon. This puts the gastrocolic ligament on some tension and helps to expose the right gastroepiploic arcade (Figure 3). Once the right gastroepiploic vessels have been identified, the division of the gastrocolic ligament is initiated usually at a point near the mid antrum. Dissection initially proceeds in a cephalad direction up the greater curvature to the level of the left gastroepiploic which is divided with the energy device (Figure 4). In overweight individuals, this part of the dissection can be challenging because of the amount of fat and one must proceed cautiously so as not to injure the splenic flexure.
Once the lesser sac has been entered, the stomach can be elevated away from the pancreas and retroperitoneum and adhesions divided sharply. Sometimes it is easier to visualize the right gastroepiploic arcade from the posterior aspect of the stomach as there may be less fat and the division of the gastrocolic ligament can be performed keeping the vascular arcade in view. To do this, the posterior wall of the stomach is grasped and elevated away from the pancreas and towards the hiatus and liver. Once the watershed between the gastroepiploic and the short gastric vessels has been reached, the division of the gastrosplenic ligament and the short gastric vessels is accomplished close to the gastric wall. This is facilitated by retracting the stomach to the patient’s right side putting the ligament on some tension (Figure 5A,B,C). Care must be taken to be sure that the jaws of the energy device are completely across each of the vessels, which are taken in sequence, partial division will result in hemorrhage. Elevating the stomach off the retroperitoneum and retracting the fundus to the patient’s right helps to expose the uppermost short gastric as well as the occasional posterior branch coming off the splenic artery. Once these vessels are divided, the fundus is completely mobilized off the retroperitoneum and the left crus (Figure 6A,B). The hiatus is then entered medial to the left crus (Figure 7).
Attention is then turned to the distal antrum. Again elevating the stomach superiorly and anteriorly, adhesions between the posterior wall of the stomach and the pancreas are divided (Figure 8A,B). The gastrocolic ligament is divided as far as the level of the pylorus being careful to avoid injury to the right gastroepiploic as it arches posteriorly to its origin off the gastroduodenal artery. It is important to carefully mobilize the filmy posterior tissues at this level to improve visualization of the arcade as well as mobility of the distal stomach (Figure 9). This allows visualization of the pedicle proceeding posteriorly and separates the pedicle from the remaining gastrocolic ligament (Figure 10). Once this dissection is completed the pylorus is visible both anteriorly and posteriorly. I do not perform a Kocher maneuver.
Left gastric artery (LGA) dissection
With the stomach otherwise fully mobilized, the left gastric pedicle is grasped near the lesser curvature and gentle cephalad traction applied. This puts the left gastric pedicle on some tension and helps to identify its origin (Figure 11). The peritoneum overlying the upper border of the pancreas is incised and then the plane of dissection deepened. The left gastric vein is divided at the base of the pedicle as it passes posteriorly and inferiorly to join the portal vein (Figure 12). The origin of the LGA and the trifurcation of the celiac artery into the LGA, common hepatic and splenic arteries is exposed (Figure 13A). It is important to see the origin of the 3 arteries as the LGA pedicle should be divided as close to its origin as possible. The LGA is skeletonized, sweeping the lymph node bearing fatty tissues up with the specimen. This dissection is facilitated by dividing the soft tissues between the origin of the LGA and the confluence of the right and left crura. The artery is taken either with an endovascular load of the endoGIA (Covidien) or if small, with clips. I previously completed the full lymph node dissection with the LGA intact (Figure 13B) and prior to creating the gastric conduit. I have found that division of the LGA and creation of the conduit allows better visualization for completion of the lymph node dissection.
Creation of the gastric conduit
Once the left gastric pedicle is divided, I create the gastric conduit. Applying traction on the fundus and opposing traction on the antrum, the creation of the conduit is initiated using an endoGIA 45 mm purple load tri stapler (Covidien) applied just below the Crow’s foot (Figure 14). Multiple applications of the endoGIA stapler using either 45 or 60 mm purple Tri-Stapler cartridges are required to create a long narrow conduit. This is facilitated by articulating the stapler rather than applying it in its straightened configuration. We have also found that this reduces the problem of “spiraling” the conduit. The width of the conduit is approximately 4 cm as measured from the staple line to the greater curvature. Usually at total of 6 cartridges are required (Figure 15A,B). I completely divide the stomach in the abdomen having abandoned the practice of leaving the upper most portion of the fundus attached early on in my experience. This allows free mobility of the proximal resected stomach and facilitates dissection at the hiatus and in the lower mediastinum. It also reduces handling of the conduit and risk of injury. Once the creation of the conduit is completed, it is positioned inferiorly to improve visualization for the lymphadenectomy.
At this point in the procedure, the left gastric nodes have been resected and are left attached to the resected proximal stomach. Beginning at the level of the left gastric stump, the peritoneum overlying the common hepatic artery is divided and then the hepatic artery is skeletonized from its origin to its division into right and left branches. The lymph node bearing tissue is then dissected off the cephalad border of the hepatic artery by gently retracting the origin of the common hepatic artery inferiorly (Figure 16A,B). When doing this, one must be aware that the portal vein lies posterior to the artery and can be exposed by retraction of the artery. Once these nodes are fully dissected, they are removed from the abdomen, usually in a sterile specimen bag and submitted as a separate specimen for pathology.
We next dissect the aortocaval nodes lying between the aorta/celiac axis and the inferior vena cava. This is accomplished using sharp dissection with the ultrasonic shears as well as blunt dissection with the suction device and/or peanut sponge. Many times there is very little tissue in this space and we do not do a formal dissection. The celiac nodes are dissected next, beginning at the level of the LGA stump and proceeding up to the confluence of the right and left crura (Figure 17). Lastly we skeletonize the splenic artery beginning at its origin and following it distally. We generally stop short of the splenic hilum but include the soft tissues overlying the retroperitoneum between the splenic artery and the left crus. Again, this is facilitated by gently retracting the pancreas inferiorly, being aware that the splenic vein lies just posterior to the artery (Figure 18). It is safest to follow the artery closely, staying right on the artery from proximal to distal, as the artery may be quite tortuous and injury can result if the surgeon deviates away from the artery (Figure 19). Once the lymphadenectomy is completed the hepatic, splenic, left gastric and celiac arteries are completely skeletonized.
All lymph nodes are submitted as separate specimens, labelled appropriately as to their origin. This facilitates accurate nodal counts as well as localization of positive nodes.
Following completion of the lymphadenectomy, we turn to the hiatal dissection. The hiatus is opened medial to the right crus. The confluence of the crura and left crus are exposed posteriorly (Figure 20). This is facilitated by retracting the resected proximal stomach to the patient’s left. I expose the descending thoracic aorta above the hiatus and skeletonize it, sweeping all the fatty tissue up with the esophagus (Figure 21). I then come around to the right and open into the right pleural space, again taking the fatty tissue superior and adjacent to the hiatus with the esophagus. I continue around anteriorly and skeletonize the posterior pericardium (Figure 22). I divide the right inferior pulmonary ligament close to the pulmonary parenchyma so that the lymph node bearing tissue in the ligament is included with our resected specimen (Figure 23). I retract the resected proximal stomach to the patient’s right and similarly resect the perihiatal fatty tissue, the left pleura and left pulmonary ligament proceeding from posterior to anterior until I join the plane of dissection on the posterior pericardium. The hiatal dissection is facilitated by retracting each crus laterally to aid visualization of the lower mediastinum. We continue the dissection as high as is comfortable. We do not attempt to completely divide the inferior pulmonary ligaments and are careful as we proceed superiorly to avoid injury to the inferior pulmonary veins.
Once the hiatal dissection is complete, we suture the tip of the conduit to the lower portion of the resected proximal stomach using two sutures to maintain orientation. The liver retractor is then removed, followed by all ports, the CO2 is evacuated from the abdomen and the port sites are closed in standard fashion. We then insert a chest tube into the left pleural space through a small incision in the left inframammary fold in the anterior axillary line. We have recently moved from 28 to 20 Fr chest tubes.
Once the abdomen is closed the patient is repositioned into the left lateral decubitus position, leaning slightly anteriorly. Many surgeons are now doing the thoracic phase in the prone position and we believe this likely offers many advantages but we have not yet made this transition. The semiprone approach is a compromise with the operating surgeon standing at the front of the patient.
Generally, we use four ports: three in the anterior axillary line 3rd, 5th and 7th interspace and one posteriorly in the 8th or 9th interspace. All port sites are infiltrated with 0.05% Marcaine with epinephrine prior to making the skin incisions. We use a closed system with CO2 insufflation to a pressure of 8 mmHg for the initial dissection. The lung is retracted anteriorly (the more prone the patient, the less retraction is required).
The pleura above and below the azygous vein arch is divided, the azygous vein skeletonized and then taken with the endo-GIA vascular load. The esophagus is gently retracted posteriorly and the pleura overlying the right main bronchus (RMB) is carefully opened beginning at the level of the divided azygous vein and proceeding inferiorly. The right vagus is divided as it crosses the RMB (Figure 24). Keeping posterior traction on the esophagus, the esophagus is mobilized off the posterior pericardium from the level of the RMB down to the level achieved by the hiatal dissection during the abdominal phase. During this dissection, we may leave the subcarinal node packet in situ or remove it with the esophagus depending on the ease of removal. As we proceed from the right RMB inferiorly, we skeletonize the right inferior pulmonary vein. The mobilization of the esophagus away from the pericardium is continued proceeding from the right toward the left until the left inferior pulmonary vein is identified and skeletonized. The esophagus is then mobilized off the distal trachea, tracheal carina and left main bronchus (Figure 25). Extreme care must be used to avoid thermal injury to the membranous airways. The LMB is particularly at risk because of distension by the bronchial balloon of the double lumen tube. Once the distal trachea and LMB are fully exposed, attention is directed to the dissection of the esophagus posteriorly.
The esophagus is retracted anteriorly, and the pleura anteromedial to the ascending azygous vein is incised beginning at the level of the divided azygous arch and proceeding inferiorly down to the hiatus (Figure 26). The esophagus is the dissected off the descending aorta (Figure 27). The aorta is skeletonized from the aortic arch down to the hiatus exposing the left lung and left inferior pulmonary ligament (Figure 28). Most of the branches off the aorta can be managed with the ultrasonic shears, but it is prudent to leave a short stump of these branches on the aortic side to allow for placement of a clip or suture, if hemostasis with the ultrasonic shears is insufficient. Particularly troublesome are two small branches arising from the undersurface of the arch itself.
If the thoracic duct is to be removed, this is accomplished as part of the skeletonization of the aorta taking care to clip the duct inferiorly just above the hiatus as well as superiorly where it crossed from right to left just at the level of the aortic arch and the arch of the azygous vein. I do not routinely take the thoracic duct.
Once the descending aorta has been skeletonized, the division of the left pleura and the left inferior pulmonary ligament is completed proceeding from the lower chest superiorly (Figure 29A,B), skeletonizing the left inferior pulmonary vein and then dividing the left vagus nerve just above the left inferior pulmonary vein. The esophagus is then fully mobilized away from the aortic arch, LMB and distal trachea (Figure 29C). At this level, dissection is kept close to the esophagus to avoid injury to the left recurrent nerve. Once the infracarinal dissection is completed, the RMB, left main bronchus, carina, right and left inferior pulmonary veins, descending aorta and posterior pericardium have been skeletonized (Figure 30).
I generally dissect the esophagus for 4–6 cm above the azygous vein and then divide the esophagus 3 cm above the divided azygous vein (Figure 31). The esophagus is divided with the ultrasonic shears as I use an EEA stapler (Covidien) for my anastomosis. If the Orvil stapler or linear stapler is to be used, the esophagus may be divided using the endoGIA stapler.
We then turn off the CO2 insufflation, and enlarge the anterior superior port. The resected proximal stomach and attached conduit are delivered into the chest and the sutures holding them together are divided. A large heavy specimen bag is then introduced into the chest, the resected specimen is placed in the bag and together they are extracted from the chest. On a back table, lymph nodes are separately harvested off and sent as separate specimens (left gastric nodes, pericardial nodes, periesophageal nodes, subcarinal nodes if attached). Margins are inspected. Generally, a margin from the divided end of the esophagus is sent for frozen section but if the gastric margin looks close, this will be sent as well.
Once the specimen is removed, we dissect out the subcarinal lymph node packet if these have been left in situ, skeletonizing the main bronchi, carina and posterior pericardium if this has not been done previously. If the upper mediastinal node dissection is performed, it is at this point in the procedure that this is undertaken. We use bipolar energy and blunt dissection for this lymphadenectomy, taking the paratracheal tissue off the lateral walls of the trachea up to the right innominate artery and the common carotid on the left. This has not been a routine part of our procedure as most of our patients have cancers of the distal esophagus and gastroesophageal junction. However, we have had late isolated recurrences in this region and are starting to incorporate the paratracheal dissection as a routine part of the operation.
I continue to use a standard EEA stapling device (Covidien) for the anastomosis. A purse string suture of 2-0 Tevdek using the EndoStitch device (Covidien) is placed (Figure 32). The EEA anvil is then introduced through the anterior access incision. Grasping the end of the esophagus at two points, the anvil is rotated into the lumen and secured in place by tying the ends of the purse-string suture (Figure 33A). We do not use the EndoStitch device for tying the first purse-string, instead we cut the suture at the level of the needle and do an intracorporeal knot using two needle holders. We then reinforce the closure with a second purse-string of 2-0 Tevdek using the EndoStitch device, this time using the device to complete the knot (Figure 33B).
The conduit is then delivered fully into the chest. Generally the distal end of the lesser curve staple line lies just above the hiatus. This leaves the portion of the antrum close to the pylorus below the diaphragm. This is important to eliminate stasis in the antrum if it is pulled into the chest and sits on the diaphragm. The conduit is delivered by applying gently upward and anterior traction to avoid trauma to the vascular pedicle. Care must be taken to ensure that the conduit is not twisted as it is delivered into the chest. The lesser curve staple line should face upward away from the mediastinum, and the vascular pedicle should face down into the mediastinum.
We then inspect the greater curve and identify the end of the right gastroepiploic arcade (Figure 34). A gastrotomy is then made adjacent to the lesser curve staple line using the L-hook opposite to the end of the right gastroepiploic arcade (Figure 35). The contents of the gastric conduit are evacuated. The EEA stapler is then introduced through the access incision, through the gastrotomy and positioned such that the point of the stapler extrudes through the greater curvature just above the end of the gastroepiploic arcade (Figure 36A). The stapler is the angled upward and docked on the previously placed anvil (Figure 36B), turned down and fired. The stapler is turned back 5 half turns and removed. The donuts are inspected and also the anastomosis is inspected through the gastrotomy (Figure 37). Finally the gastrotomy is closed and redundant stomach is resected with 1 or more firings of the endo-GIA stapler (Figure 38). We generally find we have excess conduit and by placing the anastomosis lower on the greater curve adjacent to the right gastroepiploic arcade, we are able to place the anastomosis in a well vascularized part of the stomach and resect the more ischemic upper portion of the conduit. The external aspect of the anastomosis is inspected circumferentially (Figure 39). The anastomosis may be reinforced with sutures if there are any areas of concern. The final reconstruction should lie straight without redundancy with the anastomosis high in the chest (Figure 40).
It can be difficult to advance the stapler between the ribs. Generally we use a 25 mm stapler and have found this to provide a satisfactory lumen without stricture or dysphagia. If the esophagus is very large, a 28 mm anvil may be required but it is even more difficult to pass the stapler between the ribs. Some surgeons introduce the stapler through an inferior port site where the interspaces are wider. The stapler can then be introduced into the stomach through a lesser curve gastrotomy as described or through the uppermost end of the conduit, pulling the conduit onto the stapler like a sock. My own experience with these methods is limited. When using these methods I have experienced some difficulty in placing the anastomosis exactly in the desired location on the great curve tending to always be higher than intended, but perhaps this would be overcome with more experience.
An alternative anastomotic technique uses the ORVIL device (Covidien). The Orvil device passed per os into the esophageal remnant. It can be challenging to get it to pass the upper sphincter and we have often scrubbed out to assist our anaesthesiologist with this step using a laryngoscope. A small esophagotomy is made adjacent to the stapled end of the esophageal remnant and the delivery device is advanced through the esophagotomy into the chest until the circular portion of the anvil is seated at the esophageal staple line with the post fully positioned beyond the esophagotomy. The EEA stapler is then docked on the anvil, turned down and fired. Problems have arisen with leaks, largely related to the crossing staple lines. This has led some surgeons to move the esophagotomy from the middle of the esophageal staple line to one corner or to a site positioned 1 cm away from the esophageal staple line. We have moved away from the Orvil because of our high leak rate when using the device. Surgeons who continue to use it, anecdotally report reinforcing the anastomosis with sutures, particularly where staple lines cross.
Another alternative is to use the linear endoGIA to create a side to side, functional end to end anastomosis either using the Orringer technique or a modified Collard technique. Both of these techniques require a longer length of esophageal remnant. These create a larger diameter anastomosis and are useful in a very dilated esophagus. After creating the anastomosis with the linear stapler using either a 30 or 45 mm cartridge, the front wall is sewn with a running or interrupted suture such as 3-0 PDS or Vicryl. A v-lock suture can also be used. Some surgeons report using another endo GIA to close the front wall but there is a risk of narrowing the anastomosis so we prefer to sew the front wall.
Following completion of the anastomosis, the anastomosis is submerged under warm saline and an endoscopy is performed insufflating air into the esophageal reconstruction. The absence of bubbles in the saline is reassuring that there is no technical leak. We have found this quite useful not only for the anastomosis but also for the occasional injury to the conduit, or leak at the gastric staple line. The gastroscope is advanced through the pylorus and then withdrawn verifying the correct orientation of the conduit. We find that passing the scope through the pylorus serves to dilate it somewhat.
We then place a #10 flat Jackson-Pratt drain in the posterior mediastinum adjacent to the anastomosis and a separate 20 Fr intercostal drain brought out through the inferior port site. Intercostal nerve blocks (8) are placed and the chest is closed. A nasogastric sump drain is positioned within the intrathoracic conduit.
The patient is awakened and extubated in the operating room. Postoperative pain is managed with patient controlled IV analgesia using hydromorphone. Chest tubes are removed after 48–72 hours and the JP drain is left in situ for measurement of drain amylase. The ng is usually removed after 48–72 hours although we have removed it after 24 hours.
The minimally invasive Ivor Lewis esophagectomy includes all the essential components of the open operation. There will always be some variation between surgeons. It is important that each surgeon assess their outcomes, and perfect their technique to provide the best outcome for the patient. From the oncologic perspective an R0 resection and adequate lymphadenectomy are key. From the patient perspective the ability to eat and swallow comfortably are key which relates to a reliable anastomosis that doesn’t leak or stricture and a straight nonredundant conduit that empties well. Additionally reducing reflux by placing the anastomosis as high in the chest as possible will improve patient comfort. As we improve survival from esophageal cancer with combined modality therapy and improved operations, we should strive to provide patients with the best possible quality of life.
Provenance and Peer Review: This article was commissioned by the Guest Editors (Christopher R. Morse and Uma M. Sachdeva) for the series “Minimally Invasive Esophagectomy” published in Annals of Esophagus. The article has undergone external peer review.
Conflicts of Interest: The author has completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/aoe-20-26). The series “Minimally Invasive Esophagectomy” was commissioned by the editorial office without any funding or sponsorship. The author has no other conflicts of interest to declare.
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Cite this article as: Darling GE. Ivor Lewis minimally invasive esophagectomy. Ann Esophagus 2021;4:18.