Is persistent intestinal metaplasia a prognostic factor after definitive chemoradiation in patients with esophageal adenocarcinoma?

Derek Serna-Gallegos, Inderpal S. Sarkaria


Barrett’s esophagus (BE) is defined as the replacement of the normal esophageal squamous epithelium with columnar epithelium. This process is also known as intestinal metaplasia and is a relatively common disease with a reported incidence ranging from 1.6% to 6.8% (1-3). The true incidence of BE may be even higher as studies limited to symptomatic patients will not demonstrate the true prevalence of the disease.